Sulfuric Acid → HCID 21735928, compound

Participants

Reaction Steps

To a solution of 5-nitro-1-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-2,4(1H,3H)-quinazolinedione (500 mg) in a mixture of chloroform (9 ml) and methanol (1 ml) was added 2N solution of sulfuric acid in methanol (1.19 ml) at 0° C. After evaporation of the solvent, the crystalline residue was recrystallized from 10% water in ethanol (30 ml) to give 5-nitro-1-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-2,4(1H,3H)-quinazolinedione sulfate (497 mg) as pale brown crystals.

Provenance & Evidence