Methane → HCID 19087701, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[N-{4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butylamino-6-fluorobenzamide (900 mg), trichloromethyl chloroformate (1.5 ml) and active charcoal (catalytic amounts) in dioxane (20 ml) was stirred for 1 hour at 80° C. The solvent was removed in vacuo. The residue was dissolved in 10% hydrogen chloride-methanol, then the solution was filtered. After evaporation of the filtrate, the residue was crystallized from ethanol-ether. The crude crystals were collected, and washed with hot ethanol to afford 1-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-5-fluoro-2,4(1H,3H)-quinazolinedione hydrochloride (80 mg).

Provenance & Evidence