Potassium Carbonate → HCID 15230480, compound

Participants

Reaction Steps

A mixture of 85 mg of 5-[N-(4-chlorophenyl) amino]-2-(3-pyridylmethyl)-1H-isoindole-1,3 (2H)-dione, 71 mg of iodobenzene, 30 mg of copper dust, 12 mg of 18-crown-6 (1,4,7,10,13,16-hexaoxacyclooctadecane), 128 mg of potassium carbonate and 2 ml of 1,2-dichlorobenzene was refluxed under heating for 7 hours. After finishing the reaction, the insoluble material was filtered off, and the filtrate was concentrated in vacuo. The resultant residue was chromatographed on a column of silica gel, eluting with chloroform and methanol (100:1) to give 96 mg of the titled compound.

Provenance & Evidence