HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3,5-Dichloro-4-methylbenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,5-Dichloro-4-methylbenzoic acid | HCID 18533234 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3,5-Dichloro-4-methylbenzoyl chloride | HCID 11127919 | 110.3% |
Reaction Steps
A mixture of 3,5-dichloro-4-methylbenzoic acid (230 g, 1.12 moles), thionyl chloride (204 g, 1.71 moles), and dimethylformamide (30 milliliters(ml), in toluene (1 liter) was slowly warmed to 70° C. and stirred at that temperature for 2 hours. The toluene was eliminated in the rotavap to yield 276 g of 3,5-dichloro-4-methylbenzoyl chloride, used in the next step as such.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05304572 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-773d0d4220c64bf882ca5bd1cb3030bd |
| Source note | uspto-grants-1994_04 |