反应详情

636.8 g of 6-acetyl-2-(2-aminopropionylamino)-3-(2-chlorobenzoyl)-4,5,6,7-tetrahydro-thieno[2,3-C]pyridine was dissolved in 2.3 liters of toluene, 637 ml of pyridine and 94.3 ml of acetic acid and refluxed over day and night while removing water from the reaction system. After removal of the reaction solution by distillation, benzene was added, followed by the cooling and filtering the resultant crystals to obtain 300 g of the intended product.

1. customwhile removing water from the reaction system
2. customAfter removal of the reaction solution
3. distillationby distillation, benzene
4. additionwas added
5. filtrationfiltering the resultant crystals