Propargyl bromide → 1,2-dibenzyl 1-tert.butyl 4-methyl-1-(prop-2-yn-1-yl)-1,1,2(R)-pentanetricarboxylate

Participants

Role	Name	HCID	Charge
Reactant	Propargyl bromide	HCID 7842	—
Reactant	Dibenzyl 3(RS)-tert-butoxycarbonyl-2(R)-isobutylsuccinate	HCID 18660804	—
Product	1,2-dibenzyl 1-tert.butyl 4-methyl-1-(prop-2-yn-1-yl)-1,1,2(R)-pentanetricarboxylate	HCID 86747777	103%

Reaction Steps

In a manner analogous to that described in Example 45(i), from 5.0 g of 1,2-dibenzyl 1-tert.butyl 4-methyl-1,1,2(R)-pentanetricarboxylate and 3.3 g of propargyl bromide there were obtained 5.58 g of 1,2-dibenzyl 1-tert.butyl 4-methyl-1-(prop-2-yn-1-yl)-1,1,2(R)-pentanetricarboxylate in the form of a colorless oil; MS 493 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05304549
Source dataset	uspto-grants-1994_04
ORD ID	ord-a8860720486748e292b9c70107fed8ba
Source note	uspto-grants-1994_04