Sodium Hydroxide → HCID 19087788, compound

Participants

Reaction Conditions

Reaction Steps

18.4 g (0.1 mol) of the compound from Example I are dissolved in 50 ml of DMF and 4 g (0.1 mol) of NaOH in 40 ml of methanol are added. 17.8 g (0.1 mol) of 2-chloromethylquinoline in 50 ml of DMF are added dropwise to this mixture with stirring and it is then heated at 100° C. for 5 h. After cooling, the solvent is evaporated in vacuo, the residue is taken up in dichloromethane, and the solution is washed twice with water, dried and concentrated in vacuo to a small volume. Separation is carried out by column chromatography (silica gel 60, eluent: toluene/ethyl acetate=9:1 to 8:2).

Provenance & Evidence