Sodium Hydroxide → 2-[3-Bromo-4-(quinolin-2-yl-methoxy)phenyl]acetic acid

HRID 1464380Notes

Reaction equation

HRID 1464380 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([O:23]C)=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1.[OH-].[Na+]>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:20][C:21]([OH:23])=[O:22])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19087791Methyl 2-[3-bromo-4-(quinolin-2-yl-methoxy)phenyl]acetate

Product 1

HCID 190877852-[3-Bromo-4-(quinolin-2-yl-methoxy)phenyl]acetic acid

Procedure

In analogy to the procedure of Example XV, the title compound is prepared from 3 g (7.77 mmol) of the compound from Example XX and 12 ml of 1N sodium hydroxide solution (12 mmol).

Sources & evidence

ORD record
ord-27743255dfd84de4b9d561a3b2c0ae88
Source dataset
uspto-grants-1994_04
Patent number
US05304563

Reaction notes

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