Sodium Hydroxide → 2-[3-Methoxy-4-(quinolin-2-yl-methoxy)phenyl]-acetic acid

HRID 1464383Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:21][C:22]([O:24]C)=[O:23])[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=1.[OH-].[Na+]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:21][C:22]([OH:24])=[O:23])[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 19087794Methyl 2-[3-methoxy-4-(quinolin-2-yl-methoxy)phenyl]acetate

Product 1

HCID 190877812-[3-Methoxy-4-(quinolin-2-yl-methoxy)phenyl]-acetic acid

Procedure

The title compound is prepared from 3 g (8.9 mmol) of the compound from Example XXIII and 12 ml of 1N sodium hydroxide solution analogously to the procedure of Example XV.

Sources & evidence

ORD record: ord-1589901c96a24dbaa1fc01dd3a847082
Source dataset: uspto-grants-1994_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05304563

Reaction notes

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