Water → HCID 3034572, compound

HRID 1464427Notes

Reaction equation

HRID 1464427 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[S:10]1[CH2:16][C:14](=[O:15])[NH:13][C:11]1=[S:12].C([O-])(=O)C.[Na+].O>C(O)(=O)C>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[C:16]2[S:10][C:11](=[S:12])[NH:13][C:14]2=[O:15])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 680234-FluorobenzaldehydeHCID 517045Sodium AcetateHCID 1201546Rhodanine

Product 1

HCID 3034572HCID 3034572, compoundYield 85.1%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

10 g of 4-fluorobenzaldehyde was dropwise added at room temperature to a solution having 10.8 g of rhodanine and 20 g of sodium acetate suspended in 100 ml of acetic acid. The obtained mixture was reacted under reflux for two hours and then cooled to room temperature. Then, this reaction mixture was put into about 500 ml of water, and a solid product thereby obtained was collected by filtration, washed with water and dried to obtain 16.4 g of 5-(4-fluorobenzylidene)rhodanine.

Workup

  1. customThe obtained mixture was reacted
  2. temperatureunder reflux for two hours
  3. customa solid product thereby obtained
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-50b548e69acc46679e58d32dd8b9cf7b
Source dataset
uspto-grants-1994_04
Patent number
US05304657

Reaction notes

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