Formic Acid → N-[(3S)-Tetrahydro-2,5-dioxo-3-furanyl]formamide

Participants

Reaction Steps

To 671 ml of formic acid, 226 ml of acetic acid and 226 ml of toluene was added 1437 ml of acetic anhydride. After 910 g of L-aspartic acid and 12.8 g of magnesium acetate tetrahydrate were added to the thus prepared solution, the mixture was kept at a temperature of 45° C. and reacted for 3.5 hours with stirring. To the resulting slurry was added 3970 ml of toluene. After ice-cooling for an hour with stirring, the mixture was filtered, while performing suction, to give 917 g of crystalline N-formyl-L-aspartic anhydride.

Provenance & Evidence