Sulfuric Acid → L-Phenylalanine, methyl ester

Participants

Reaction Conditions

Reaction Steps

To a mixture of 10.2 liters of methanol and 335 ml of conc. sulfuric acid was added 1050 g of L-phenylalanine. The mixture was stirred at 90° C. for 5 hours to effect esterification. The reaction solution was adjusted with 15% sodium carbonate aqueous solution to a Ph of 7. L-Phenylalanine methyl ester was extracted with toluene to give 10.7 liters of toluene solution of L-phenylalanine methyl ester.

Provenance & Evidence