Dimethylamine → 3-(3,5-Di-t-butyl-2-hydroxyphenyl)-2,2-dimethylpropanal

Participants

Reaction Steps

125 g (1 mol) of 80% strength aqueous 2,2-dimethyl-3-hydroxypropanal (crude mixture from the synthesis, reduced to a water content of 20% by distillation), 185 g (0.9 mol) of 2,4-di-t-butylphenol, 24 g (0.22 mol) of 40% strength aqueous dimethylamine and 700 g of methanol are reacted in a stirred autoclave under autogenous pressure of 20-30 bar at 160° C. for 20 h and then at 180° C. for 20 h. Workup of the reaction mixture by distillation yields 159 g (61%) of 3-(3,5-di-t-butyl-2-hydroxyphenyl)-2,2-dimethylpropanal (boiling point 115°-116° C.).

Provenance & Evidence