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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14645Generated: October 29, 2026

Hydrochloric Acid → 1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid benzyl-(2-dimethylamino-ethyl)-amide

https://huagongshe.com/reaction/14645

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant{4-[Benzyl-(2-dimethylamino-ethyl)-carbamoyl]-6,8-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl esterHCID 68613386—
SolventEthyl AcetateHCID 8857—
Product1-Aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid benzyl-(2-dimethylamino-ethyl)-amideHCID 46846941100.6%

Reaction Steps

As described in example 1, 91 mg of {4-[benzyl-(2-dimethylamino-ethyl)-carbamoyl]-6,8-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 74 mg (>100%) of 1-aminomethyl-6,8-dimethoxy-isoquinoline-4-carboxylic acid benzyl-(2-dimethylamino-ethyl)-amide MS: APCI (M+H) calc'd for C24H30N4O3+H 423.5; found 423.2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732446B1
Source datasetuspto-grants-2010_06
ORD IDord-1bf089bb81f44c9b9073166a534fb480
Source noteuspto-grants-2010_06