HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-1-hexanol → tert-Butyl N-(6-hydroxyhexyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-1-hexanol | HCID 19960 | — |
| Reactant | 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile | HCID 93865 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | tert-Butyl N-(6-hydroxyhexyl)carbamate | HCID 4146612 | 106.7% |
Reaction Steps
Four grams of 6-amino-1-hexanol (34.1 mmols) was dissolved in 30 ml of chloroform and ice-cooled. Seven grams of 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile (BOC-ON) dissolved in 20 ml of chloroform was added, and the mixture was ice-cooled and reacted for 16 hours. Chloroform was evaporated, and the residue was separated and purified by silica gel column chromatography to obtain 6.59 g of the captioned compound. Yield: 89 %.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05306617 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-95876869716c4791800e581622c6539b |
| Source note | uspto-grants-1994_04 |