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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1464556Generated: October 31, 2026

5-Aminosalicylic Acid → 2-hydroxy-4-[(phenoxycarbonyl)amino]benzoic acid

https://huagongshe.com/reaction/1464556

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Aminosalicylic AcidHCID 4075—
Reactant4-Aminosalicylic AcidHCID 4649—
ReactantPhenyl chloroformateHCID 15891—
ReactantSodium BicarbonateHCID 516892—
Product2-hydroxy-4-[(phenoxycarbonyl)amino]benzoic acidHCID 249994—
ProductHCID 249995HCID 249995—

Reaction Steps

In the preparation process described in J. Pharm. Sci., 52, 927 (1963), 4-aminosalicylic acid and 5-aminosalicylic acid is reacted with phenylchloroformate in an aqueous sodium hydrogen carbonate solution to obtain 4-phenyloxycarbonylaminosalicylic acid and 5-phenyloxycarbonylaminosalicylic acid, respectively, in the relatively high yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05306688
Source datasetuspto-grants-1994_04
ORD IDord-f1ea4df59e7e4c3a87eec08fa2fc3995
Source noteuspto-grants-1994_04