Hydrochloric Acid → HCID 11324315, compound

Participants

Reaction Steps

To 700 ml of methanol suspended 153 g of 4-aminosalicylic acid and 84 g of sodium hydrogen carbonate, 193 g of n-octylchloroformate was dropwise added over 2 hours at room temperature. After finishing dropwise addition, the mixture was further stirred for 2 hours at room temperature. An aqueous solution containing 30 g of concentrated hydrochloric acid and 1200 ml of water was added to the reaction mixture. Precipitated crystals were filtered and dried to obtain 300 g of desired 4-(n-octyloxycarbonylamino)salicylic acid as colorless crystals. Yield was 97%.

Provenance & Evidence