Hydrochloric Acid → HCID 11324315, compound

Participants

Reaction Steps

To an aqueous solution dissolved 153 g of 4-aminosalicylic acid and 170 g of sodium hydrogen carbonate in 2200 ml of water, 193 g of n-octylchloroformate was dropwise added over 2 hours at room temperature. After finishing dropwise addition, the mixture was further stirred for 5 hours at room temperature. An aqueous solution containing 30 g of concentrated hydrochloric acid and 1200 ml of water was added to the reaction mixture. Precipitated crystals were filtered and dried to obtain 148 g of desired 4-(n-octyloxycarbonylamino)salicylic acid as colorless crystals. Yield was 48%.

Provenance & Evidence