Potassium Carbonate → HCID 19086731, compound

Participants

Reaction Steps

Ethyl 2-(6-hydroxyindazol-1-yl)propionate (30 mgs) was dissolved in 0.72 cm3 of a mixture of dry methyl isobutyl ketone (6cm3) and 1 drop of dry DMF. 3-chloro-4,5-difluorobenzotrifluoride (42 mg) and dry potassium carbonate (27mg) were added. The mixture was stirred and heated under reflux for 7 hours, additional dry potassium carbonate being added after 3 hours. After cooling, the solvents were removed under vacuum and diethyl ether added to the residue, the mixture filtered and the inorganic portion washed thoroughly with diethyl ether. The combined ethereal filtrate was concentrated under vacuum and the residue purified by chromatography (SiO2 ; hexane:t-butylmethylether,4:1) to give compound 1, ethyl 2-[6-(2-chloro- 4-trifluoromethyl-6-fluorophenoxy) indazol-1-yl]propionate (29 mg). M+ =430.

Provenance & Evidence