Sodium Hydroxide → HCID 21687336, compound

Participants

Reaction Steps

Ethyl 2-[6-(2-chloro-6-fluoro-4-trifluoromethylphenoxy)indazol-1-yl]propionate prepared as described in Example 2 (30 mgs) was dissolved in THF (0.1 cm3) and isopropanol (0.28 cm3). 1.73M sodium hydroxide (0.04 cm3) was added and the mixture stirred at room temperature for 8 hours and left to stand overnight. The solvent was removed under vacuum and the residue dissolved in water (2 cm3). 2M hydrocloric acid (0.035 cm3) was added dropwise with stirring. After 1.5 hours the solid product was filtered off, washed with water and air dried to give 2-[6-(2-chloro-6-fluoro-4-trifluoromethylphenoxy) indazol-1-yl]propionic acid (11 mgs) as a white solid. Compound No 4 was prepared by an analogous process using appropriate reactants.

Provenance & Evidence