Potassium Carbonate → HCID 178510659, compound

Participants

Reaction Steps

4-(2-chloro-4-trifluoromethyl-6-fluorophenoxy)-2-nitro-N-cyanomethylaniline (1 g) was suspended in hot ethanol (50cm3) and anhydrous potassium carbonate (0.18 g) added. The mixture was then stirred under reflux for 4 hours and left at room temperature overnight. The solvent was evaporated from the mixture under vacuum and the residue dissolved in water (75cm3), filtered and acidified with 2M hydrochloric acid. The yellow precipitate was collected and washed with water, then hexane and air dried to give 2-cyano-5-(2-chloro-4-trifluoromethyl-6-fluorophenoxy)-1H-benzimidazole-3-oxide (0.8 g). M+ =370.

Provenance & Evidence