Potassium Carbonate → Ethyl 2-[2-cyano-5-(2-chloro-4-trifluoromethyl-6-fluorophenoxy)benzimidazol-1-yl]propionate

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Reaction Steps

2-Cyano-5-(2-chloro-4-trifluoromethyl-6-fluorophenoxy)benzimidazole (0.325 g), ethyl 2-bromopropionate (0.13cm3) and anhydrous potassium carbonate (1 g) were heated under reflux in acetonitrile (30cm3) for 2 hours and left at room temperature overnight. The mixture was filtered and the solvent removed from the filtrate under vacuum. The residue was purified by preparative plate chromatography (SiO2 ; hexane:ether,1:1) to yield ethyl 2-[2-cyano-6-(2-chloro-4-trifluoromethyl-6-fluorophenoxy)benzimidazol-1-yl]-propionate (0.14 g) as the faster component (compound 101) and ethyl 2-[2-cyano-5-(2-chloro-4-trifluoromethyl-6-fluorophenoxy)benzimidazol-1-yl]propionate (0.15 g) as the slower component (compound 100).

Provenance & Evidence