HCID 70047877, compound → 6-[4-(N-methylacetylamino)-1-piperidyl]-3,4-dihydrocarbostyril

Participants

Reaction Steps

1.25 Grams of methyl 3-[4-(N-methylacetylamino)1-piperidyl]-6-nitrocinnamate was dissolved in 50 ml of ethanol, then 0.4 g of 10%-palladium carbon was added thereto, the reaction mixture was stirred until the absorption of hydrogen gas was stopped under conditions of at room temperature and normal pressure. The catalyst was removed by filtration, the filtrate was concentrated by evaporating the solvent, the residue thus obtained was purified by means of a silica gel column chrmatography (eluent: dichloromethane:methanol=50:1), then recrystallized from methanol-diethyl ether to yield 0.82 g of 6-[4-(N-methylacetylamino)-1-piperidyl]-3,4-dihydrocarbostyril. Light yellow needle-like crystals. Melting point: 195°-197° C.

Provenance & Evidence