Benzylamine → HCID 19086853, compound

HRID 1464616Notes

Reaction equation

HRID 1464616 reaction equation
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)=[O:9])[CH2:4][CH2:3]1.[CH2:21]([NH2:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(Cl)(Cl)Cl>[CH2:21]([N:28]=[C:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)=[O:9])[CH2:4][CH2:3]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 19086843HCID 19086843, compound

Product 1

HCID 19086853HCID 19086853, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

0.8 Gram of 6-(4-oxo-1-piperidyl)carbonyl-3,4-dihydrocarbostyril, 1.6 ml of benzylamine and 1 g of Molecular Sieve 3A (a trademark for synthetic feldspar manufactured by Linde Co., U. S. A.) were drspersed in 15 ml of chloroform and refluxed by heating for 6 hours. Molecular Sieve 3A was removed by filtration, the filtrate was concentrated, then the residue obtained was washed several times with diethyl ether, next, purified by means of a silica gel column chromatography to obtain 6-(4-benzylimino-1-piperidyl)carbonyl-3,4-dihydrocarbostyril.

Workup

  1. temperaturerefluxed
  2. temperatureby heating for 6 hours
  3. customMolecular Sieve 3A was removed by filtration
  4. concentrationthe filtrate was concentrated
  5. customthe residue obtained
  6. washwas washed several times with diethyl ether
  7. customnext, purified by means of a silica gel column chromatography

Sources & evidence

ORD record
ord-37c01e49728f4d6a85cd6edb5985e16a
Source dataset
uspto-grants-1994_04
Patent number
US05306719

Reaction notes

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