HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1464632Generated: October 31, 2026
Ammonium Hydroxide → 2-Amino-pyrazino[2,3-b]pyridine
https://huagongshe.com/reaction/1464632
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-Chloropyrido[2,3-b]pyrazine | HCID 21856172 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-Amino-pyrazino[2,3-b]pyridine | HCID 19087110 | — |
Reaction Steps
A mixture of 2-chloro-pyrazino[2,3-b]pyridine (3.35g), isopropanol (20 mL) and concentrated ammonium hydroxide (50 mL) was heated at 115° C. for 17 h in a sealed tube. The tube was cooled and the product was collected and recrystallized from ethanol to afford 2-amino-pyrazino[2,3-b]pyridine as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05306819 |
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| Source dataset | uspto-grants-1994_04 |
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| ORD ID | ord-1bcb73e2563b4b7ebaf84d2454ea9024 |
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| Source note | uspto-grants-1994_04 |
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