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Sodium Carbonate → 2-(p-Chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Methanesulfenyl chloride, trifluoro- | HCID 67900 | — |
| 反応物 | 2-(4-Chlorophenyl)-1h-pyrrole | HCID 272428 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Diethylether water | HCID 21584184 | — |
| 生成物 | 2-(p-Chlorophenyl)-5-[(trifluoromethyl)thio]pyrrole | HCID 18930423 | — |
反応手順
Trifluoromethylsulfenyl chloride is bubbled into a solution of 2-(p-chlorophenyl)pyrrole (0.5 g, 0.00281 mol) and sodium carbonate (0.36 g, 0.00338 mol) in ether at -30° C. under nitrogen. The reaction mixture is stirred for 1/2 hour and diluted with a water/ether mixture. The organic phase is separated, washed with brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title product as a purple solid (0.78 g, mp 34°-39° C.) which is identified by 1HNMR and 13CNMR spectral analyses.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05306827 |
| 出典データセット | uspto-grants-1994_04 |
| ORD ID | ord-b4fab61c4ffa4f1d9a8151536aaa7bed |
| 出典メモ | uspto-grants-1994_04 |