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Trichloroacetyl chloride → 5-(p-Chlorophenyl)pyrrol-5-yl trichloromethyl ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trichloroacetyl chloride | HCID 6420 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-(4-Chlorophenyl)-1h-pyrrole | HCID 272428 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-(p-Chlorophenyl)pyrrol-5-yl trichloromethyl ketone | HCID 18930394 | 77.7% |
反応手順
A solution of trichloroacetyl chloride (11.26 g, 0.0619 mol) in ether is treated with a solution of 2-(p-chlorophenyl)pyrrole (10.0 g, 0.0503 mol) in ether, stirred for four hours at room temperature, treated with saturated potassium carbonate solution and diluted with ethyl acetate. The organic phase is separated, washed with brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain a yellow solid. The solid is recrystallized from 2-propanol to give the title product as a yellow solid (12.63 g, mp 166°-168° C.) which is identified by 1HNMR spectral analysis.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05306827 |
| 出典データセット | uspto-grants-1994_04 |
| ORD ID | ord-9d1f87d5eba44bb3b33d4bc1ab6d5b5d |
| 出典メモ | uspto-grants-1994_04 |