反应详情

温度

200 °C

0.8 g of anhydrous aluminium chloride was added to 50 g of 2,6-dimethylphenyl chloroformate and the mixture was heated to 200° C. at normal pressure. The evolution of carbon dioxide started above 180° C. and finished after 3.5 hours. The reaction mixture was then cooled, water was added, the organic phase was separated off, the aqueous phase was extracted with methylene chloride, the organic phase which had been separated off was combined with the methylene chloride phase and the combined phases were dried over sodium sulphate and distilled under vacuum. 2,6-Dimethylchlorobenzene was obtained in a yield of 64%.

1. customstarted above 180° C.
2. temperatureThe reaction mixture was then cooled
3. customthe organic phase was separated off
4. extractionthe aqueous phase was extracted with methylene chloride
5. customthe organic phase which had been separated off
6. dry with materialthe combined phases were dried over sodium sulphate
7. distillationdistilled under vacuum