(E)-2-[3-[3-(3-thienyl)phenyl]-2propenyloxy]ethanol → (E,E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-2-[3-[3-(3-thienyl)phenyl]-2-propenyloxy]ethylamine hydrochloride

HRID 1464740Notes

Reaction equation

HRID 1464740 reaction equation
C(N)C=CC#CCC.[S:9]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[C:16](/[CH:20]=[CH:21]/[CH2:22][O:23][CH2:24][CH2:25]O)[CH:17]=[CH:18][CH:19]=2)=[CH:10]1.[ClH:27].[CH2:28]([NH:30][CH2:31]/[CH:32]=[CH:33]/[C:34]#[C:35][C:36]([CH3:39])([CH3:38])[CH3:37])[CH3:29]>>[ClH:27].[CH2:28]([N:30]([CH2:25][CH2:24][O:23][CH2:22]/[CH:21]=[CH:20]/[C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([C:11]2[CH:12]=[CH:13][S:9][CH:10]=2)[CH:15]=1)[CH2:31]/[CH:32]=[CH:33]/[C:34]#[C:35][C:36]([CH3:37])([CH3:39])[CH3:38])[CH3:29]

Participants

4

Reactant 3

HCID 19916999(E)-2-[3-[3-(3-thienyl)phenyl]-2propenyloxy]ethanolHCID 19917114(E)-N-ethyl-6,6-dimethyl-2-hepten-4-ynylamine hydrochlorideHCID 540733612-Hepten-4-ynylamine

Product 1

HCID 19916994(E,E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-2-[3-[3-(3-thienyl)phenyl]-2-propenyloxy]ethylamine hydrochloride

Procedure

Compounds of Examples 26 to 29 were obtained by performing the same reaction as in Example 25 except that the corresponding alcohol derivatives and/or 2-hepten-4-ynylamine derivatives were used instead of the starting compounds, (E)-2-[3-[3-(3-thienyl)phenyl]-2propenyloxy]ethanol and/or (E)-N-ethyl-6,6-dimethyl-2-hepten-4-ynylamine hydrochloride, which were used in the above-mentioned reaction.

Workup

  1. customwere used in the above-mentioned reaction

Sources & evidence

ORD record
ord-b9155659f657451aafce774d6c3e7742
Source dataset
uspto-grants-1994_04
Patent number
US05306728

Reaction notes

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