HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1464769Generated: October 30, 2026
Ethyl Acetate → 3-[3-(3-Thienyl)phenoxy] propanal dimethylacetal
https://huagongshe.com/reaction/1464769
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromopropionaldehyde dimethylacetal | HCID 118932 | — |
| Reactant | 3-(Thiophen-3-YL)phenol | HCID 4130343 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[3-(3-Thienyl)phenoxy] propanal dimethylacetal | HCID 19917057 | — |
Reaction Steps
1.3 g of 3-(3-thienyl)phenol, 1.09 ml of 3-bromopropanal dimethylacetal and 1.1 g of potassium carbonate were dissolved in 10 ml of dimethylformamide, and the mixture was heated at 90° C. with stirring for 6 hours. Ethyl acetate and water were added, and the organic layer separated was worked up in a customary manner, then the product was purified by silica gel column chromatography [hexane / ethyl acetate=30/1→20/1] to give 1.0 g of 3-[3-(3-thienyl)phenoxy] propanal dimethylacetal as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05306728 |
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| Source dataset | uspto-grants-1994_04 |
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| ORD ID | ord-4c11c325e40045ff9cb39e902e35bc2d |
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| Source note | uspto-grants-1994_04 |
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