Ethylamine → N-cyclopropyl-2-[2-[3-(3-thienyl)phenoxy]ethoxy}ethylamine
Reaction equation
C(N)C.FCCN.[CH:8]1([NH:11][C:12](=O)[CH2:13][O:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]3[CH:28]=[CH:27][S:26][CH:25]=3)[CH:19]=2)[CH2:10][CH2:9]1.C(NCCOCCOC1C=CC=C(C2C=CSC=2)C=1)C.FCCNCCOCCOC1C=CC=C(C2C=CSC=2)C=1>>[CH:8]1([NH:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([C:24]3[CH:28]=[CH:27][S:26][CH:25]=3)[CH:19]=2)[CH2:10][CH2:9]1Participants
6
Reactant 5
Product 1
Procedure
When the same reactions as in Referential Example 34 are carried out using ethylamine or 2-fluoroethylamine instead of the starting cyclopropylamine, N-ethyl-2-[2-[3-(3-thienyl)phenoxy]ethoxy]ethylamine and N-(2-fluoroethyl)-2-[2-[3-(3-thienyl)phenoxy]ethoxy]ethylamine are obtained.
Workup
- customare obtained
Sources & evidence
- ORD record
- ord-07711fc5899b4e4e8fe4aa9e0fa75ea5
- Source dataset
- uspto-grants-1994_04
- Patent number
- US05306728
Reaction notes
Loading…