Methanesulfonyl chloride → HCID 86747789, compound

Participants

Reaction Conditions

Reaction Steps

2-[3-(3-thienyl)phenyl]ethyl methanesulfonate, [synthesized by reacting 100 mg of 2-[3-(3-thienyl)phenoxy]ethanol with 50 μl of methanesulfonyl chloride and 190 μl of triethylamine in 1 ml of ethyl acetate] was dissolved in 1.5 ml of dimethylformamide, and 68 mg of potassium thioacetate was added. The mixture was heated at 80° C. with stirring for 3 hours, and then water and ethyl acetate were added. The organic layer separated was worked up in a customary manner to give 111 mg of S-[2-[3-(3-thienyl)phenoxy]ethyl] thioacetate as a pale brown oil.

Provenance & Evidence