Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 5-Bromosalicylaldehyde | HCID 72863 | — |
| Reactant | 1-[4-(Benzyloxy)phenyl]-2-bromoethan-1-one | HCID 10542593 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 19918524 | HCID 19918524 | — |
Reaction Steps
5-Bromosalicylaldehyde (2.9 g, 14.5 mmol), cesium carbonate (2.5 g, 7.7 mmol) and acetonitrile (40 ml) were combined and heated to reflux for 30 minutes. The mixture was cooled to 0° C. and a solution of 4'-benzyloxy-2-bromoacetophenone (J. Het. Chem., 2, 310 (1965)) (4.7 g, 15 mmol) in acetonitrile (20 ml) was added. The cooling bath was removed, the mixture stirred at room temperature for 2.5 hours and the precipitate collected (4.5 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05306726 |
|---|
| Source dataset | uspto-grants-1994_04 |
|---|
| ORD ID | ord-ecd70f2c6c9644d2833234c6e5c3f301 |
|---|
| Source note | uspto-grants-1994_04 |
|---|
