Ammonium Chloride → HCID 66747415, compound

Temperature

-20 °C

4-Isobutyl-6-methylcyclohex-3-enecarbaldehyde 3b (23 g, 130 mmol) was dissolved in diethyl ether (200 ml). The solution was cooled to −20° C. under nitrogen and MeLi (1.6M, 100 ml, 160 mmol) added over 30 min with stirring. The temperature was allowed to rise to −5° C. and the reaction stirred at this temperature for 1 h. The reaction mixture was poured slowly, and under nitrogen, onto a vigorously stirred mixture of sat. NH4Cl (150 ml) and ice (100 g). After stirring for 15 min the phases were separated and the lower aqueous layer extracted with diethyl ether (100 ml). The organic phases were combined, washed with water (100 ml), dried (Na2SO4) and concentrated in vacuo to give 24 g of a light yellow oil. The crude oil was purified by flash chromatography (MTBE/hexane 1:3) to give 4b as a 3:2 mixture of diastereomers (18 g, 72% yield, colorless oil, >99% pure). Subsequent distillation provided 12.5 g of olfactory pure product.

1. customto rise to −5° C.
2. stirringthe reaction stirred at this temperature for 1 h
3. additionThe reaction mixture was poured slowly
4. stirringAfter stirring for 15 min the phases
5. customwere separated
6. extractionthe lower aqueous layer extracted with diethyl ether (100 ml)
7. washwashed with water (100 ml)
8. dry with materialdried (Na2SO4)
9. concentrationconcentrated in vacuo

ORD record

ord-dbf879e34bc84f7ab3133b43a0f6cc79

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08999914B2