Adipic Acid → HCID 56929677, compound

HRID 1464939Notes

Reaction equation

HRID 1464939 reaction equation
[C:1]([OH:10])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].[Cl:11][C:12]1[CH:13]=[CH:14][C:15]2[CH2:21][CH2:20][NH:19][CH2:18][C@H:17]([CH3:22])[C:16]=2[CH:23]=1>CC(C)=O>[C:1]([OH:10])(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7].[Cl:11][C:12]1[CH:13]=[CH:14][C:15]2[CH2:21][CH2:20][NH:19][CH2:18][C@H:17]([CH3:22])[C:16]=2[CH:23]=1

Participants

4

Reactant 2

HCID 196Adipic AcidHCID 11658860Lorcaserin

Product 1

HCID 56929677HCID 56929677, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine adipate salt was prepared by addition of adipic acid (0.5-1 eq.) in acetone to a solution of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine at ˜62° C. Precipitation occurred within 5 min and the suspension was allowed to cool to ambient temperature with stirring. (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine adipate salt had multiple endothermic events by DSC starting at onset temperatures between 104° C. and 107° C.

Workup

  1. customPrecipitation
  2. customstarting at onset temperatures between 104° C. and 107° C.

Sources & evidence

ORD record
ord-8fe9edbace3c42fe91f9e72c24b9408e
Source dataset
uspto-grants-2015_04
Patent number
US08999970B2

Reaction notes

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