HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → HCID 131732661, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lorcaserin | HCID 11658860 | — |
| Solvent | Isopropyl Acetate | HCID 7915 | — |
| Product | HCID 131732661 | HCID 131732661 | — |
Reaction Steps
(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine citrate salt hemihydrate was prepared by dropwise addition of 1 mole equivalent of citric acid in hot MeOH to a solution of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine in isopropyl acetate. Precipitation occurred spontaneously. (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine citrate salt hemihydrate had a dehydration onset temperature by DSC of about 80° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08999970B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-551bd28d46fd4e4d8e7b1635ee8dcd82 |
| Source note | uspto-grants-2015_04 |