Succinic Acid → HCID 66613436, compound

HRID 1464944Notes

Reaction equation

HRID 1464944 reaction equation
[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:11]=[CH:12][C:13]2[CH2:19][CH2:18][NH:17][CH2:16][C@H:15]([CH3:20])[C:14]=2[CH:21]=1>CCO.C(OC(C)C)(=O)C>[C:1]([OH:8])(=[O:7])[CH2:2][CH2:3][C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:11]=[CH:12][C:13]2[CH2:19][CH2:18][NH:17][CH2:16][C@H:15]([CH3:20])[C:14]=2[CH:21]=1

Participants

5

Reactant 2

HCID 1110Succinic AcidHCID 11658860Lorcaserin

Product 1

HCID 66613436HCID 66613436, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 7915Isopropyl AcetateSolvent

Procedure

(R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine succinate salt was prepared by the addition of succinic acid (0.5-1 eq.) in hot EtOH to a solution of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine in isopropyl acetate. After overnight stirring, a solid was recovered by suction filtration and washed in isopropyl acetate. (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine succinate salt had an extrapolated melting onset temperature by DSC of about 179.1° C.

Workup

  1. filtrationa solid was recovered by suction filtration
  2. washwashed in isopropyl acetate. (R)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine succinate salt
  3. customby DSC of about 179.1° C.

Sources & evidence

ORD record
ord-e32df1558d1f4ad49166f783ee27ee2e
Source dataset
uspto-grants-2015_04
Patent number
US08999970B2

Reaction notes

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