Hydrogen chloride-ethyl acetate → (3-Fluoro-4-methylphenyl)(piperazin-1-yl)methanone hydrochloride

HRID 1464958Notes

Reaction equation

HRID 1464958 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:20]=[CH:21][C:22]=1[CH3:23])[C:5]([N:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)=[O:6].[ClH:24].CCOC(C)=O>>[ClH:24].[F:1][C:2]1[CH:3]=[C:4]([C:5]([N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)=[O:6])[CH:20]=[CH:21][C:22]=1[CH3:23]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66748119HCID 66748119, compound

Product 1

HCID 45791551(3-Fluoro-4-methylphenyl)(piperazin-1-yl)methanone hydrochloride

Procedure

A mixture of tert-butyl 4-(3-fluoro-4-methylbenzoyl)piperazine-1-carboxylate (3.14 g, 9.74 mmol) and 4 M HCl-EtOAc was stirred at rt for 20 h. After removing the solvent, the residue was suspended in EtOAc, and the white precipitate was collected by filtration to give 1.97 g (78% yields) of the title compound as a white solid.

Workup

  1. customAfter removing the solvent
  2. filtrationthe white precipitate was collected by filtration
  3. customto give

Sources & evidence

ORD record
ord-0b6b9c77d6164eefb103336e47425735
Source dataset
uspto-grants-2015_04
Patent number
US08999974B2

Reaction notes

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