Isobutanol → HCID 56655170, compound

Participants

Reaction Steps

To a suspension of sodium hydride (60% in mineral oil, 20 mg, 0.52 mmol) in DMF was added 2-methylpropan-1-ol (39 mg, 0.52 mmol) at rt. After stirring at rt for 15 min, (4-(6-chloropyrimidin-4-yl)piperazin-1-yl)(3-fluoro-4-methylphenyl)methanone (35 mg, 0.11 mmol) was added to the mixture. After stirring at rt for 12 h, the mixture was poured onto water (5 mL), and the aqueous phase was extracted with dichloromethane (three times). The combined organic layers were dried over sodium sulfate and concentrated in vacuo. The residue was purified by preparative LC-MS to give 14.4 mg (37% yields) of the title compound.

Provenance & Evidence