Potassium Phosphate, Tribasic → HCID 56651722, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)	HCID 636044	—
Reactant	HCID 31097182	HCID 31097182	—
Reactant	HCID 61278956	HCID 61278956	—
Catalyst	Bis(dibenzylideneacetone)palladium	HCID 9811564	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 56651722	HCID 56651722	—

Reaction Conditions

Temperature	100 °C

Reaction Steps

A mixture of 4-chloro-6-isobutoxypyrimidine (50 mg, 0.27 mmol), 4-(3-fluoro-4-methylbenzoyl)piperazin-2-one (76 mg, 0.32 mmol), tris(dibenzylideneacetone)dipalladium (12 mg, 0.013 mmol), Xantphos (23 mg, 0.040 mmol), and tripotassium phosphate (85 mg, 0.40 mmol) in dioxane (5 mL) was stirred at 100° C. for 12 h. After cooling to rt, the mixture was poured onto water, and the aqueous layer was extracted with dichloromethane (twice). The combined organic layer was dried over sodium sulfate and concentrated in vacuo. The residue was purified by preparative LC-MS to give 4.3 mg (4% yields) of the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08999974B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-921bef34c1b348f4947c1293e7bebc5e
Source note	uspto-grants-2015_04