Formamide → 3H,4H-thieno[3,2-d]pyrimidin-4-one

Participants

Role	Name	HCID	Charge
Reactant	Formamide	HCID 713	—
Reactant	Methyl 3-amino-2-thiophenecarboxylate	HCID 89652	—
Product	3H,4H-thieno[3,2-d]pyrimidin-4-one	HCID 135417422	—

Reaction Conditions

Temperature	180 °C

Reaction Steps

Methyl-3-aminothiophene-2-carboxylate (15 g, 98.57 mmol) (Matrix, Cat #018289, CAS [22288-78-4]) was dissolved in formamide (50 mL), and the mixture was stirred at 180° C. for 5 hours. The reaction mixture was further stirred at room temperature for 2 hours and then filtered to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08999973B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-76a1dc287d2d4d97b40e88a0a0796b58
Source note	uspto-grants-2015_04