HCID 67359144, compound → HCID 67359462, compound

HRID 1464980Notes

Reaction equation

HRID 1464980 reaction equation
[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8](/[CH:11]=[CH:12]/[C:13]3[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=3[CH3:22])[C:16]([OH:18])=O)[C:4]=2[N:5]=[CH:6][N:7]=1.[CH2:23]([N:25]1[CH2:30][CH2:29][N:28]([C:31]2[CH:32]=[C:33]([CH:35]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:37]=2)[NH2:34])[CH2:27][CH2:26]1)[CH3:24]>>[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8](/[CH:11]=[CH:12]/[C:13]3[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=3[CH3:22])[C:16]([NH:34][C:33]3[CH:35]=[C:36]([C:38]([F:39])([F:40])[F:41])[CH:37]=[C:31]([N:28]4[CH2:29][CH2:30][N:25]([CH2:23][CH3:24])[CH2:26][CH2:27]4)[CH:32]=3)=[O:18])[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 67359144HCID 67359144, compoundHCID 67359350HCID 67359350, compound

Product 1

HCID 67359462HCID 67359462, compound

Procedure

The procedure of Step 5 of Example 1 was repeated except for using (E)-3-(2-(4-aminothieno[3,2-d]pyrimidine-7-yl)vinyl)-4-methylbenzoic acid and 3-(4-ethylpiperazine-1-yl)-5-(trifluoromethyl)aniline to obtain the title compound (see Table 1).

Sources & evidence

ORD record
ord-040c6a0783ac4b5191e36e22e33964c4
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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