4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline → HCID 67360698, compound

HRID 1464990Notes

Reaction equation

HRID 1464990 reaction equation
[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([C:11]([NH:13][C:14]3[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=3[CH3:23])[C:17]([OH:19])=O)=[O:12])[C:4]=2[N:5]=[CH:6][N:7]=1.[CH2:24]([N:26]1[CH2:31][CH2:30][N:29]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([NH2:39])=[CH:35][C:34]=2[C:40]([F:43])([F:42])[F:41])[CH2:28][CH2:27]1)[CH3:25]>>[NH2:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([C:11]([NH:13][C:14]3[CH:15]=[C:16]([C:17](=[O:19])[NH:39][C:36]4[CH:37]=[CH:38][C:33]([CH2:32][N:29]5[CH2:28][CH2:27][N:26]([CH2:24][CH3:25])[CH2:31][CH2:30]5)=[C:34]([C:40]([F:43])([F:42])[F:41])[CH:35]=4)[CH:20]=[CH:21][C:22]=3[CH3:23])=[O:12])[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 591345644-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)anilineHCID 67360239HCID 67360239, compound

Product 1

HCID 67360698HCID 67360698, compound

Procedure

The procedure of Step 5 of Example 1 was repeated except for using 3-(4-aminothieno[3,2-d]pyrimidine-7-carboxamido)-4-methylbenzoic acid obtained in Step 4 of Example 8 and 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzenamine to obtain the title compound (see Table 1).

Sources & evidence

ORD record
ord-343c9b23b3bf4240afdf359ba10da4ce
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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