Benzoyl Peroxide → HCID 18176289, compound

HRID 1465002Notes

Reaction equation

HRID 1465002 reaction equation
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.C1C(=O)N([Br:19])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:19][CH2:11][C:8]1[C:4]2[N:5]=[CH:6][N:7]=[C:2]([Cl:1])[C:3]=2[S:10][CH:9]=1

Participants

5

Reactant 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 27775864-Chloro-7-methylthieno(3,2-d)pyrimidine

Product 1

HCID 18176289HCID 18176289, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Conditions

Temperature
100 °C

Procedure

4-Chloro-7-methylthieno[3,2-d]pyrimidine (6.62 g, 33.0 mmol) and NBS (5.87 g, 33.0 mmol) were dissolved in CCl4 (100 mL) and benzoylperoxide (1.0 g, 80% purity) was added thereto. The reaction mixture was stirred at 100° C. for an hour, cooled to room temperature, filtered with Celite and concentrated to obtain the title compound having a yellow color without further purification.

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered with Celite
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-10b4f4c1a72e4444ab2add12f3fae1fb
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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