HCID 86674138, compound → HCID 86674139, compound

HRID 1465005Notes

Reaction equation

HRID 1465005 reaction equation
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH2:11][OH:12])[C:4]=2[N:5]=[CH:6][N:7]=1>C(Cl)(Cl)Cl.O=[Mn]=O>[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH:11]=[O:12])[C:4]=2[N:5]=[CH:6][N:7]=1

Participants

4

Reactant 1

HCID 86674138HCID 86674138, compound

Product 1

HCID 86674139HCID 86674139, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6212ChloroformSolvent

Conditions

Temperature
70 °C

Procedure

(4-Chlorothieno[3,2-d]pyrimidine-7-yl)methanol (215 mg, 0.99 mmol) and MnO2 (863 mg, 9.9 mmol, 10 eq) were dissolved in chloroform (10 mL) and stirred at 70° C. for 2 hours. The reaction mixture was cooled to room temperature, filtered with Celite and concentrated to obtain the title compound as a white solid without further purification.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. filtrationfiltered with Celite
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-4911bc22663143bdbbd6146c2cadc932
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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