反应详情

温度

0 °C

NaH2PO4.2H2O (170 mg, 1.07 mmol) was dissolved in water (0.6 mL) and 4-chlorothieno[3,2-d]pyrimidine-7-carbaldehyde (100 mg, 0.47 mmol) dissolved in DMSO (4.8 mL) was added thereto at 10° C. The reaction mixture was cooled to 0° C. and NaClO2 (170 mg, 1.88 mmol) dissolved in water (0.6 mL) was added thereto at 0° C. The reaction mixture was heated to room temperature, stirred for 2 hours, and water (10 mL) was added thereto. The reaction mixture was stirred for 2 hours and then filtered. The filtrate was concentrated to obtain the title compound as a white solid.

1. additionwas added
2. customat 10° C
3. additionwas added
4. customat 0° C
5. temperatureThe reaction mixture was heated to room temperature
6. stirringThe reaction mixture was stirred for 2 hours
7. filtrationfiltered
8. concentrationThe filtrate was concentrated