3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline → HCID 53345643, compound

HRID 1465017Notes

Reaction equation

HRID 1465017 reaction equation
[CH:1]1([NH:4][C:5]2[C:6]3[S:13][CH:12]=[C:11]([C:14]([NH:16][C:17]4[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=4[CH3:26])[C:20]([OH:22])=O)=[O:15])[C:7]=3[N:8]=[CH:9][N:10]=2)[CH2:3][CH2:2]1.[CH3:27][C:28]1[N:29]=[CH:30][N:31]([C:33]2[CH:34]=[C:35]([CH:37]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:39]=2)[NH2:36])[CH:32]=1>>[CH:1]1([NH:4][C:5]2[C:6]3[S:13][CH:12]=[C:11]([C:14]([NH:16][C:17]4[CH:18]=[C:19]([C:20](=[O:22])[NH:36][C:35]5[CH:37]=[C:38]([C:40]([F:41])([F:42])[F:43])[CH:39]=[C:33]([N:31]6[CH:32]=[C:28]([CH3:27])[N:29]=[CH:30]6)[CH:34]=5)[CH:23]=[CH:24][C:25]=4[CH3:26])=[O:15])[C:7]=3[N:8]=[CH:9][N:10]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 120028253-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)anilineHCID 67360952HCID 67360952, compound

Product 1

HCID 53345643HCID 53345643, compound

Procedure

The procedure of Step 5 of Example 1 was repeated except for using 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylbenzoic acid obtained in Step 3 of Example 21 and 3-(4-methyl-1H-imidazole-1-yl)-5-(trifluoromethyl)aniline to obtain the title compound (see Table 1).

Sources & evidence

ORD record
ord-77164dfb1abb4eb7bf9c097b4910562e
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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