6-(Morpholino)pyridin-3-amine → HCID 53345540, compound

HRID 1465018Notes

Reaction equation

HRID 1465018 reaction equation
[CH:1]1([NH:4][C:5]2[C:6]3[S:13][CH:12]=[C:11]([C:14]([NH:16][C:17]4[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=4[CH3:26])[C:20](O)=[O:21])=[O:15])[C:7]=3[N:8]=[CH:9][N:10]=2)[CH2:3][CH2:2]1.[O:27]1[CH2:32][CH2:31][N:30]([C:33]2[N:38]=[CH:37][C:36]([NH2:39])=[CH:35][CH:34]=2)[CH2:29][CH2:28]1>>[CH:1]1([NH:4][C:5]2[C:6]3[S:13][CH:12]=[C:11]([C:14]([NH:16][C:17]4[CH:18]=[C:19]([C:20](=[O:21])[NH:39][C:36]5[CH:37]=[N:38][C:33]([N:30]6[CH2:29][CH2:28][O:27][CH2:32][CH2:31]6)=[CH:34][CH:35]=5)[CH:23]=[CH:24][C:25]=4[CH3:26])=[O:15])[C:7]=3[N:8]=[CH:9][N:10]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 1040596-(Morpholino)pyridin-3-amineHCID 67360952HCID 67360952, compound

Product 1

HCID 53345540HCID 53345540, compound

Procedure

The procedure of Step 5 of Example 1 was repeated except for using 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylbenzoic acid obtained in Step 3 of Example 21 and 6-morpholinopyridine-3-amine to obtain the title compound (see Table 1).

Sources & evidence

ORD record
ord-d10907bc3a6c4203bba24481dc95ee18
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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