6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → HCID 53345642, compound

HRID 1465019Notes

Reaction equation

HRID 1465019 reaction equation
[CH:1]1([NH:4][C:5]2[C:6]3[S:13][CH:12]=[C:11]([C:14]([NH:16][C:17]4[CH:18]=[C:19]([CH:23]=[CH:24][C:25]=4[CH3:26])[C:20]([OH:22])=O)=[O:15])[C:7]=3[N:8]=[CH:9][N:10]=2)[CH2:3][CH2:2]1.[CH2:27]([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[N:40]=[CH:39][C:38]([NH2:41])=[CH:37][CH:36]=2)[CH2:31][CH2:30]1)[CH3:28]>>[CH:1]1([NH:4][C:5]2[C:6]3[S:13][CH:12]=[C:11]([C:14]([NH:16][C:17]4[CH:18]=[C:19]([C:20](=[O:22])[NH:41][C:38]5[CH:39]=[N:40][C:35]([N:32]6[CH2:33][CH2:34][N:29]([CH2:27][CH3:28])[CH2:30][CH2:31]6)=[CH:36][CH:37]=5)[CH:23]=[CH:24][C:25]=4[CH3:26])=[O:15])[C:7]=3[N:8]=[CH:9][N:10]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 91616746-(4-Ethylpiperazin-1-yl)pyridin-3-amineHCID 67360952HCID 67360952, compound

Product 1

HCID 53345642HCID 53345642, compound

Procedure

The procedure of Step 5 of Example 1 was repeated except for using 3-(4-(cyclopropylamino)thieno[3,2-d]pyrimidine-7-carboxamido)-4-methylbenzoic acid obtained in Step 3 of Example 21 and 6-(4-ethylpiperazine-1-yl)pyridine-3-amine to obtain the title compound (see Table 1).

Sources & evidence

ORD record
ord-95682c12a5eb4c2a843a3427a234d5be
Source dataset
uspto-grants-2015_04
Patent number
US08999973B2

Reaction notes

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