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HRID1465054

反应详情

EQUATION

反应方程式

HRID 1465054 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)n1nc(N)c2c1C(C)(C)N(C(=O)OC(C)(C)C)C2
HCID57353085

5-tert-Butyl 1-ethyl 3-amino-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate

C15H24N4O4

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1Cc2c(N)n[nH]c2C1(C)C
HCID40152088

tert-Butyl 3-amino-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate

C12H20N4O2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Reagent 5-tert-butyl 1-ethyl 3-amino-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate, E1(I), (10.97 g, 33.9 mmol) was dissolved in MeOH (200 mL) after which NaOH (5 eq, 169 mmol) was added. After stirring the mixture at room temperature for 3 h, the starting material disappeared. After removal of MeOH, add H2O and AcOEt was added, and the product was extracted with AcOEt and dried over Na2SO2 followed by concentration to afford E1(II).

WORKUP

后处理

  1. additionwas added
  2. customAfter removal of MeOH
  3. additionadd H2O and AcOEt
  4. additionwas added
  5. extractionthe product was extracted with AcOEt
  6. dry with materialdried over Na2SO2
  7. concentrationfollowed by concentration
  8. customto afford E1(II)